Instead of getting drain cleaners with strong chemicals that can have detrimental effects, it’s recommended to consider the eco-friendlier alternative of enzyme drain cleaners. They’re often more reliable compared to regular drain cleaners as they make use of biological cleaning power to keep the septic tank and plumbing system clean. The powerful mixture of special enzymes will break down any gunk just like other drain cleaners but with an improved effect of dealing with offensive smells as well. Although enzymatic drain cleaners act slower than other chemical-laden solutions, they’re preferable for the health of your pipes.
Another great benefit of an enzyme drain cleaner is that you can often use it for other purposes as well. It’s recommended for septic tank maintenance but you can also rely on it for cleaning tasks such as removing persistent pet odors from carpets. Keep in mind that enzyme drain cleaners may not be ideal for very tough plumbing obstructions as they’re mainly designed for regular maintenance and the prevention of such issues in the first place. Take a look at the following selection of the most performant and cost-effective enzyme drain cleaners on the market right now.
Best Septic Tank Enzyme Cleaner
1. Green Gobbler Septic Saver Enzyme Drain Cleaner

If you’re searching for a reliable enzyme drain cleaner for your septic tank, check out this model from Green Gobbler. As its name suggests, the Septic Saver relies on a powerful combination of enzymes to ensure that your sewer line stays free of any organic matter or various types of dirt. A single 7.8oz bag should suffice for maintaining the health of the septic tank for approximately 6 months.
One great advantage of this product over regular septic tank cleaners involves the ability to reduce odors in a significant way. The specially-formulated enzymes will digest any stuck organic waste while providing a fresh scent. Using the enzyme drain cleaner correctly requires just dropping a single pod and flushing the toilet. There’s no need to worry about pipe damage while the strength of the enzymes should be enough even for commercial applications.
2. Bio-Clean Enzyme Drain Cleaner

An effective drain cleaning solution, the special enzyme-based formulation from Bio-Clean keeps your plumbing system clear of any obstructions. This is a reliable drain treatment product that’s eco-friendly considering the use of natural bacteria and enzymes specially designed for annihilating organic waste. Instead of worrying about a disaster, this drain cleaner can provide some great peace of mind. It’s recommended for both prevention and to fix slow running drains.
With the help of a single 2lbs canister, you should be able to enjoy approximately 100 drain treatments. It’s all about following the correct dosing instructions to allow the enzymes to work effectively. This product won’t make wonders in the short-term but it can offer great plumbing cleaning results in the long-term. In a matter of days, you can expect better drain flow thanks to the all-natural formulation that’s slow yet very reliable.
Best Enzyme Drain Strips
3. Green Gobbler BIO-Flow Enzyme Drain Strips

With a simple strip form, the Green Gobbler BIO-Flow represents a more practical enzymatic drain cleaning solution. Each strip boasts a concentrated formula that will also provide any plumbing system with a fresher scent. Due to reliable enzymes, all organic materials encountered are digested so you no longer have to worry about drain maintenance. The slow process ensures that over time the drain line will remain free of any stuck waste.
Although the strips are fully packed with enzymes, they won’t dissolve quickly. This is important for allowing the bacteria to work their magic. Each pack contains a total of 12 strips with enzyme-cleaning power. It’s recommended to use a single strip each month to maintain the drain flow at the proper capacity. With the help of the Green Gobble BIO-Flow, it’s safe to say that clogs and foul drain odors will be things of the past.
Best Professional Enzyme Drain Cleaner
4. Rid-X Septic Tank Enzyme Cleaner

There are lots of great enzyme drain cleaners on the market but the Rid-X is one of the most powerful when it comes to professional septic tank treatment. This product works best for tanks with a maximum capacity of 1,500 gallons. It uses natural bacteria and enzymes that will immediately get to digesting organic waste after easy pouring and toilet flushing.
This is an excellent cleaning solution to prevent the unpleasant situation of a septic tank back-up. It will maintain the whole plumbing system free of obstructions to benefit from the full flow capacity of the drain. A single 48oz treatment bottle can cover the needs of a healthy septic tank for six months. You just need to remember to use it every month to get the expected results. The Rid-X septic tank enzyme cleaner is approved by USDA as a fully natural product that’s both safe and effective.
5. SANI 360° Enzyme Drain Sticks

Non-toxic and cost-effective, the SANI 360° enzyme drain sticks deliver excellent cleaning performance. This is a large 48-pack that enables users to prevent clogged drains for a very long time. Enzymes digest any type of organic waste materials stuck in your plumbing system while removing unpleasant odors. There are different scents available such as lemon, pine, lavender, and rose. You can also opt for an unscented option.
It’s recommended to opt for the large 48 pack of enzyme-cleaning sticks to get the best bang for your buck but you can also get a smaller 24 pack version. The thin stick design of this product makes it more practical to use for both home and business applications. It’s engineered to slowly release the army of digesting enzymes for safe yet effective removal of organic deposits and grease.
6. Flo-Kem Flo-Zyme Enzyme Drain Cleaner

Anyone who needs a commercial-grade enzyme drain cleaner should check out the Flo-Kem Flo-Zyme. It makes use of an extra-strong formula that’s not just reliable at prevention. You can also depend on it for opening up clogged drains. Organic waste products are quickly liquified and digested by specialized bacteria. This is an environmentally-friendly alternative to other chemicals considering the non-toxic and safe formulation with more than 200 billion enzymes per gallon.
The enzyme drain cleaner is also performant in terms of tackling unpleasant odors coming from the drain. A full dissolving of all the accumulated organic material can take quite a long time. It’s safe to say that you shouldn’t expect instant miracles but the enzymes are strong enough to be used for regular drain maintenance. The biobased formula is recommended if you wish to protect marine life and avoid very strong chemicals in your cleaning products.
7. AmazonCommercial Multi-Purpose Enzyme Cleaner

The AmazonCommercial multi-purpose enzyme cleaner isn’t specifically formulated for drains but it brings some advantages for those looking for a more versatile product. Thanks to a multi-purpose enzyme cleaning solution, you will be able to tackle a wider variety of jobs involving the breakdown of organic waste. It offers great all-around cleaning results while leaving behind only a fresh mint scent.
This product has a great formulation that’s not corrosive or flammable. You can use it with confidence for drain cleaning or for handling some difficult tasks such as removing stubborn grease and stains from carpets. As its name suggests, this multi-purpose enzyme cleaner is part of Amazon’s Commercial lineup of more professional-grade cleaning products. It comes in a large one-gallon size that’s very cost-effective if you need to deal with multiple cleaning projects.

